Thermogen

LOSEBiG THERMOGEN

The Science of Metabolic Activation

Metabolism is not just calorie numbers. It is the body’s rhythm, adaptability and ability to convert energy into movement and combustion. When metabolic pathways are functioning properly, the body doesn’t store – it uses. It doesn’t hold – it consumes.

LOSEBiG THERMOGEN is a scientifically designed thermogenic and metabolic support formula, based on plant extracts, bioactive polyphenols and micronutrients that act synergistically for:

• activation of metabolic mechanisms,
• increase in energy expenditure,
• support fat burning,
• better sugar control and appetite control.

The Composition That Works with Your Body

• Metabolaid® Complex (Lemon Verbena & Hibiscus) – 500 mg
  Patented herbal complex that has been studied for its action in activating AMPK, the basic “energy sensor” of cells. Supports increased energy consumption, reduction of fat mass and appetite regulation.
• Apple Cider Vinegar – 450 mg
  Contributes to satiety and postprandial glucose regulation, helping the body avoid insulin spikes that lead to fat storage.
• Soya Lecithin – 390 mg
  Source of phospholipids involved in lipid transport, cell membrane structure and metabolic flux of fatty acids.
• Green Tea Extract (50% EGCG) – 180 mg
  Green tea catechins enhance fatty acid oxidation and thermogenesis, increasing energy expenditure at rest and during exercise.
• Zinc Picolinate – 9 mg
  Zinc contributes to the normal functioning of macronutrient metabolism and the regulation of hormones related to appetite and energy.
• Cayenne Pepper – 15 mg
  Capsaicin gently increases thermogenesis and energy consumption by activating calorie burning mechanisms.
• Berberis aristata (85% Berberine) – 30 mg
  Berberine supports glucose and lipid regulation, activates AMPK and helps improve metabolic response.
• White Mulberry Leaf Extract – 150 mg
  Reduces the absorption of carbohydrates from the intestine and helps to stabilize sugar levels, limiting lipogenesis.

The Science of Synergy

LOSEBiG THERMOGEN does not target a single pathway but a complete metabolic system:

• Activation of metabolism through AMPK (Metabolaid®, Berberine, EGCG).
  – Increase thermogenesis with capsaicin and green tea polyphenols.
  – Improve fatty acid burning through phospholipids and catechins.
  – Sugar & appetite regulation with apple cider vinegar and white mulberry.
  – Stable metabolic performance without stimulants and caffeine.

Daily Dose & Method of Use

• Dose: 3 capsules daily
  – Intake: 1 capsule in the morning, 1 capsule in the early afternoon and 1 capsule in the evening with water
  – Duration: daily use or 12-week cycles
  – Suitable: For long-term metabolic support without nervous stimulation

Composition table & Action – LOSEBiG THERMOGEN

Documented Effect according to the Literature

Based on human and preclinical studies of the ingredients:

• Increase in metabolic activity: ~5-10%
  – Increase in fat burning: ~10-17%
  – Time of onset of action: 10-14 days of continuous use
  – Additional weight loss:
  – ~2-4 kg in 8-12 weeks
  – mainly from fat mass
  (when combined with a mild caloric deficit)

The effects vary according to gender, age, diet and physical activity.

Index

• Support metabolism and thermogenesis
  – Support fat burning
  – Sugar and appetite regulation
  – Support weight loss programs
  – Daily use without caffeine

The Scientific Bibliography of LOSEBiG THERMOGEN Ingredients

1. Herranz-López M, et al.
   Lemonverbena and hibiscus polyphenols modulate metabolic syndrome biomarkers through AMPK activation.
   2019;11(2):289.
   → Documentation of AMPK activation, improvement of metabolic markers and fat mass (Metabolaid®).
2. Malagón-Ruiz J, et al.
   Abotanical blend of Lippia citriodora and Hibiscus sabdariffa improves body composition in overweight subjects.
   Applied Sciences. 2024;14(9):3882.
   → Reduction of fat mass and body weight in 12 weeks without lifestyle changes.
3. Kondo T, et al.
   Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects.
   Bioscience, Biotechnology, and Biochemistry. 2009;73(8):1837-1843.
   → Documentation of the role of apple cider vinegar in weight and satiety management.
4. Hursel R, Westerterp-Plantenga MS.
   Catechin-and caffeine-rich teas for control of body weight in humans.
   Am J Clin Nutr. 2013;98(6):1682S-1693S.
   → Thermogenesis and increased fat oxidation via catechins (EGCG).
5. Dulloo AG, et al.
   Efficacy of green tea extract rich in catechin polyphenols and caffeine in increasing energy expenditure.
   Am J Clin Nutr. 1999;70(6):1040-1045.
   → Increase in energy expenditure and lipolysis.
6. Zhang Y, et al.
   Berberine activates AMPK and improves lipid metabolism.
   2014;63(3):360-368.
   → AMPK mechanism, lipid and glucose regulation.
7. Yin J, et al.
   Efficacy of berberine in patients with metabolic disorders.
   2008;57(5):712-717.
   → Clinical evidence for improving metabolic parameters.
8. Asano N, et al.
   Mulberry leaf extract inhibits intestinal disaccharidase activity and suppresses postprandial hyperglycemia.
   JAgric Food Chem. 2001;49(8):4208-4213.
   → Reduction of carbohydrate absorption, sugar control.
9. Yoneshiro T, et al.
   Capsaicin and capsinoids increase energy expenditure through brown adipose tissue activation.
   Am J Clin Nutr. 2012;95(4):845-850.
   → Thermogenesis and increased calorie burning via capsaicin.
10. Marreiro DN, et al.
    Zincand its role in energy metabolism and appetite regulation.
    Biol Trace Elem Res. 2017;179(2):1-9.
    → Role of zinc in metabolic and hormonal balance.
11. Küllenberg D, et al.
    Health effects of phospholipids in lipid metabolism.
    Lipids in Health and Disease. 2012;11:3.
    → Phospholipids & lipid metabolism (lecithin).